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摘要:Aquaporin 5 has been recently found as an important oncogenic marker whose expression levels seem to be determined by the level of cellular differentiation. Despite aquaporin volume decrease (AVD) being the most conserved earliest event in apoptosis, there is still a paucity of studies exploring on aquaporin expression and its relationship with apoptosis in cancer. The aim of this study was to investigate the expression of aquaporin 5 channel protein and to explore on its relationship with apoptosis in well and poorly differentiated non-small cell lung carcinoma both style="font-size:12px;font-family:Verdana;">in-vivo style="font-size:12px;font-family:Verdana;"> and style="font-size:12px;font-family:Verdana;">in-vitro style="font-size:12px;font-family:Verdana;">. Findings from the study showed that the expression of AQP5 both style="font-size:12px;font-family:Verdana;"> in-vivo style="font-size:12px;font-family:Verdana;"> and style="font-size:12px;font-family:Verdana;">in-vitro style="font-size:12px;font-family:Verdana;">was dependent on the type and degree of tumour differentiation. style="font-size:12px;font-family:Verdana;">In-vivo style="font-size:12px;font-family:Verdana;">, an increase in aquaporin 5 expression was associated with an increased apoptosis in both poorly and highly differentiated adenocarcinoma (AC) while there was no association between aquaporin 5 expression and apoptosis in both poorly and highly differentiated squamous cell carcinoma (SCC). style="font-size:12px;font-family:Verdana;">In vitro style="font-size:12px;font-family:Verdana;">, differentiation therapy in the form of ATRA decreased both cell proliferation and increased the expression of AQP5 in A549 cells. The cytomorphological changes, expression of differentiation markers and flow cytometry apoptotic results were dependent on the dose of ATRA treatment. In conclusion, a higher expression of aquaporin 5 was found to promote the rate of the apoptotic process in lung adenocarcinoma (AC)....
摘要:The solitary pulmonary nodule (SPN) is frequently seen on chest radiographs and computed tomography (CT), usually the identification is accidental. The overall prevalence of malignancy is relatively low but identification of malignancy of nodule is of prime importance. There are different characters of nodules indicating malignancy, and also the exposure of person to risk factors increases the chances of malignancy of nodule. Chances of malignancy rise with increasing size, the irregular, lobulated border of the nodules is highly associated with higher probability of malignancy and nodules with pure ground grass appearance have higher probability of malignancy, irregularly marginated nodule displaying a corona radiata sign indicating neoplastic infiltration with distortion of neighbouring tissue is almost certainly a malignant nodule. Stippled, punctuate, and eccentric calcifications are suggestive of malignancy. style="font-family:Verdana;">There are 20% - 75% of chances of malignancy if nodule is appeared with ground-glass opacity. Malignant nodules have higher growth rate as compared with benign nodules, malignant nodules usually have doubling time (DT) of 30 - 400 days while DT of more than 450 days is sign of benignity whereas doubling time less than 30 days is usually acute infectious process. The presence of fat within nodule is sign of benignity. Increasing density of the nodule is suggestive of malignancy and requires shorter follow up. Besides the nodule evaluation the chances of malignancy can also be evaluated through the exposure of patient to risk factors like age, current and past smoking status and history of extra thoracic malignancy. The management depends upon various factors mainly three strategies are applied for management including careful observation of nodule, use of diagnostic techniques like CT FNA, PET, and broncoscopy and surgery....
摘要:

style="font-size:10.0pt;font-family:"">Background: Previous studies reported that non-small cell carcinoma patients characterized by female gender, never-smoking status and adenocarcinoma histology were more likely to harbor epidermal growth factor receptor (EGFR) mutations. However, some studies failed to find the relationship between EGFR mutation and gender. style="font-size:10.0pt;font-family:"">Methods: One hundred and eighty-four consecutive patients (90 men and 94 women) of resected lung adenocarcinoma were studied retrospectively. Since the smoking rate is significantly higher in men, we assumed that gender difference might be a seeming factor affected by smoking. Therefore we subdivided the patients into 2 groups: never- and ever-smokers. Results: The number of ever-smokers was 94.44% in men, whereas 8.51% in women. EGFR mutation was positive in 48.9%. For overall patients, EGFR mutation status was associated with gender, pStage, pT status, lepidic dominant histologic subtype, pure/mixed groundglass opacity (GGO) on computed tomography (CT) and smoking status. However, in ever-smokers, EGFR mutation status was associated with lepidic histologic subtype and GGO on CT, but not others including gender. Similar results were also found in never-smokers, and gender was not also related to EGFR mutation in never smokers. style="font-size:10.0pt;font-family:""> style="font-size:10.0pt;font-family:"">Conclusion: The EGFR mutational frequency among men and women was not significantly different when lung adenocarcinoma patients were stratified into never- and ever-smokers.

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摘要:Background: Crizotinib is a tyrosine kinase inhibitor of ALK, MET and ROS1. In a safety database trial, it was suggested an association of Crizotinib with the development of renal cyst in patients with non-small-cell lung cancer (NSCLC). Aim: To report an uncommon side effect of Crizotinib in a patient with NSLC. Case Presentation: We report the case of a 68-year-old woman with NSCLC who developed bilateral progressive aseptic renal abscesses during Crizotinib treatment. Conclusion: Further studies may be necessary to determinate the risk of renal cyst development and the management of these complications....
摘要: style="text-align:justify;"> style="font-family:Verdana;">Background: The pleural lavage cytology (PLC) for non-small cell lung cancer (NSCLC) patients has been reported as a significant prognostic factor. The aim of this study is to clarify the clinicopathological characteristics of 5-year survivors of patients with positive PLC. Methods: Among 401 resected NSCLC patients, 30 (7.48%) patients with positive PLC were reviewed retrospectively. Results: Only 7 of 30 patients (23.3%) survived more than 5-year. There were no differences in age, gender, histology, pT status and pN status between 5-year survivors and non-survivors. On the other hand, the serum carcinoembryonic antigen (CEA) level was significantly higher in non-survivors. Among these 5-year survivors, 4 of 7 patients died of NSCLC recurrences more than 5 years after surgery. Remaining 3 patients survived without cancer recurrences. Interestingly these 3 survivors had not received any adjuvant therapies after surgery. Conclusion: None of the 5-year survivor with positive PLC had high serum CEA level. Furthermore 5-year survival did not equal to cure in NSCLC patients with positive PLC.

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摘要:

style="font-size:10.0pt;font-family:;" "=""> style="font-size:12px;font-family:Verdana;">Background: Forkhead box P3 (FOXP3) has been found to be overexpressed by a range of cancer cells and correlated with prognosis of tumors. This finding raises the possibility that the development of anti-FOXP3 antibody test may be useful for clinical application. Objective: The present work was designed to test whether circulating autoantibody to FOXP3 was altered in lung cancer. Methods: 271 patients with non-small cell lung cancer (NSCLC) and 227 in control subjects matched in age, gender and smoking history were recruited. Circulating anti-FOXP3 IgG antibody was tested using an in-house enzymelinked immunosorbent assay. Results: Student's style="font-size:12px;font-family:Verdana;">t style="font-size:12px;font-family:Verdana;">-test showed that the levels of IgG autoantibody to FOXP3 were significantly higher in patients with NSCLC than control subjects ( style="font-size:12px;font-family:Verdana;">t style="font-size:12px;font-family:Verdana;">= 7.67, style="font-size:12px;font-family:Verdana;">P style="font-size:12px;font-family:Verdana;">< 0.0001). Receiver operating characteristic (ROC) analysis showed that the area under the ROC curve (AUC) was 0.70 (95% CI style="font-size:12px;font-family:Verdana;">0.65 - 0.75 style="font-size:12px;font-family:Verdana;">, SE ± 0.024), in which style="font-size:12px;font-family:Verdana;">patients at stage 2 had the highest AUC of 0.75 ( style="font-size:12px;font-family:Verdana;">95%CI 0.67 - 0.81, SE ± 0.037 style="font-size:12px;font-family:Verdana;">) style="font-size:12px;font-family:Verdana;">, with a sensitivity of 31.4% against a specificity of 90.3%. Analysis of quality control samples gave an inter-assay deviation of 13.3% among 45 plates tested. Conclusions: Circulating IgG autoantibody to FOXP3 may be a potential biomarker for lung cancer.

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摘要:

style="font-size:10.0pt;font-family:;" "=""> style="font-family:Verdana;">Chronic obstructive pulmonary disease is an inflammatory condition with increased risk of lung cancer. We hypothesized that curcumin/ bioperine (CB), which has anti-inflammatory effects, may reduce cytological abnormalities in the sputum of patients with COPD. We conducted a 3-month, three-to-one randomized, doubleblind, pilot trial of escalating doses of CB in patients with moderate or worse COPD who were capable of producing sputum. The primary efficacy endpoint style="font-family:Verdana;">was changed in sputum cytology. We also explored changes in fluorescence in situ hybridization (FISH). We obtained sputum samples for cytology and chromosome abnormalities at baseline and each monthly follow-up visit. We enrolled 57 participants, with 35 completing the study. The participants' mean age (standard deviation [SD]) was 66.6 (8.2) years, and they were mainly male (91.2%), with an average of 63.8 pack-years of smoking history. Also, 42.1% of participants were active smokers and the mean (SD) FEV1 was 37% (13%). At baseline, 13 subjects had moderate or worse dysplasia (22.8%). Subjects with moderate to severe sputum dysplasia had more chromosome abnormalities in epithelial cells and neutrophils, as measured by deletion and aneuploidy in 10q22.3. The changes in sputum cytology and chromosome abnormalities did not differ between the active and placebo arms. CB was well tolerated at the bid doses of 1, 1.5, and 2 gm of curcumin and 5 mg of bioperine, with minor side effects related to the gastrointestinal tract. In this short pilot trial, CB compared to placebo did not alter cytological and chromosomal abnormalities seen in sputum of patients with COPD.

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摘要:Objectives: style="font-family:;" "=""> style="font-family:Verdana;">We retrospectively analyzed whether the severity of Chronic Obstructive Pulmonary Disease (COPD) affect style="font-family:Verdana;">ed style="font-family:Verdana;"> disease-specific survival in Non-Small-Cell Lung Cancer (NSCLC) patients after surgical resection. Methods: style="font-family:;" "=""> style="font-family:Verdana;">We enrolled 210 style="font-family:;" "=""> style="font-family:Verdana;">NSCLC patients who underwent curative surgery between 2009 and 2011. Classification of COPD severity was based on guidelines of the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Results: style="font-family:;" "=""> style="font-family:Verdana;">A total of 55 patients were diagnosed with COPD. style="font-family:;" "=""> style="font-family:Verdana;">The 5-year disease-specific style="font-family:;" "=""> style="font-family:Verdana;">survival of patients with COPD was not different compared with that of patients without COPD. Among the COPD patients, 40 were classified as GOLD 1, 13 as GOLD 2, and 2 as GOLD 3. Although the number of patients with GOLD 2 style="font-family:;" "=""> style="font-family:Verdana;">- style="font-family:;" "=""> style="font-family:Verdana;">3 was small, the 5-year disease-specific style="font-family:;" "=""> style="font-family:Verdana;">survival of patients with GOLD 2 style="font-family:;" "=""> style="font-family:Verdana;">- style="font-family:;" "=""> style="font-family:Verdana;">3 was significantly poorer. We found the prognostic significance of GOLD 2 style="font-family:;" "=""> style="font-family:Verdana;">- style="font-family:;" "=""> style="font-family:Verdana;">3 in univariate analysis style="font-family:Verdana;">, style="font-family:Verdana;"> but failed to find this in multivariate analysis. Conclusions: style="font-family:;" "=""> style="font-family:Verdana;">There is a possibility that the severity of COPD might be useful to predict the prognosis of NSCLC patients. style="font-family:;" "=""> style="font-family:Verdana;">Further studies with large study population are needed....
摘要:

style="font-size:10.0pt;font-family:;" "=""> style="font-family:Verdana;font-size:12px;">Chronic exposure to cigarette smoke is the leading cause of human lung cancer and its most prevalent form, adenocarcinoma. However, the mechanisms by which smoking induces adenocarcinoma are largely inferred from the analysis of fully developed tumors. The current work focuses on the early events that precede the existence of clinically detectable tumors and where the progressive mechanisms are believed to be different from the ones driving established tumor growth. Biological information was drawn from the literature and generalized into a conceptual model, or framework, which describes and integrates the main processes involved in style="font-family:Verdana;font-size:12px;">the early stages of smoking-induced lung style="font-family:Verdana;font-size:12px;">adenocarcinoma development. No such integrative representation currently exists. The biological framework presented here is based on the “field of injury” of the lung. It covers the smoking-induced stepwise transition of unexposed (naive) lung tissue to the first appearance of neoplastic cells through defined tissue states referred to as pre-field and field. Each tissue state exhibits its own formalized characteristics (or phenotype properties), which evolve as a result of the combined effects of smoking, the interactions between the different tissue properties, and the local environment represented in the framework as lung inflammation and immune surveillance. The resulting network of influences between the lung tissue states and properties provides a good understanding of the early events involved in lung adenocarcinoma triggered by smoking. The resulting conceptual model style="font-family:Verdana;font-size:12px;">—an integrative mechanistic hypothesis—can explain a broad range of cigarette smoking and smoking cessation scenarios.

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摘要: style="text-align:justify;"> "="" style="line-height:1.5;font-family:Verdana;">Purpose: To evaluate the feasibility of biweekly administration of cisplatin and vinorelbine as adjuvant chemotherapy for patients with completely resected non-small cell lung cancer (NSCLC). Patients and Methods: This was a single-arm, single-institutional study. Patients with completely resected NSCLC (p-Stage IB-IIIA) with no previous chemotherapy or radiotherapy were eligible. Simon "="" style="line-height:1.5;font-family:Verdana;">' "=""> style="font-family:Verdana;">s optimal two-stage design was applied. Both cisplatin (50 mg/m style="font-family:Verdana;">2 style="font-family:Verdana;">) and vinorelbine (25 mg/m style="font-family:Verdana;">2 style="font-family:Verdana;">) were given on days 1 and 15, every 28 days. The primary endpoint of this study was the feasibility of this combination in the four cycles of treatment. Results: "=""> "=""> style="font-family:Verdana;">Twenty patients (19 lobectomies and 1 pneumonectomy) were enrolled in this study. 10 style="font-family:Verdana;">(50%) of patients had grade 3/4 neutropenia, and 3 (15%) had grade 3/4 anemia. Severe non-hematologic toxicities were uncommon in this series. No treatment-related death was encountered. 18 (90%) patients completed the planned 4 cycles of chemotherapy. The median intensity was 24.3 (range 18.1 to 25) mg/m style="font-family:Verdana;">2 style="font-family:Verdana;">/week with an average of 23.6 (21 "=""> "="" style="line-height:1.5;font-family:Verdana;">- "=""> "=""> style="font-family:Verdana;">25) mg/m style="font-family:Verdana;">2 style="font-family:Verdana;">/week cisplatin and 12.5 (range "=""> "=""> style="font-family:Verdana;">10 to 12.5) mg/m style="font-family:Verdana;">2 style="font-family:Verdana;">/week with an average of 12.3 (10 "=""> "="" style="line-height:1.5;font-family:Verdana;">- "=""> "=""> style="font-family:Verdana;">12.5) mg/m style="font-family:Verdana;">2 style="font-family:Verdana;">/week vinorelbine. The median relative dose intensity of cisplatin was 97.5 "="" style="line-height:1.5;font-family:Verdana;">% "="" style="line-height:1.5;font-family:Verdana;"> (range 72.5 "="" style="line-height:1.5;font-family:Verdana;">% "="" style="line-height:1.5;font-family:Verdana;"> to 100 "="" style="line-height:1.5;font-family:Verdana;">% "="" style="line-height:1.5;font-family:Verdana;">) with an average of 94.6 "=""...
摘要: class="MsoNormal" style="text-align:justify;"> lang="EN-US" style="font-size:10pt;font-family:'}', serif;"> style="font-size:12px;font-family:Verdana;">Radiation therapy is a key weapon in the modern arsenal of cancer treatment. However, this effective treatment comes with risks of its own, and the sheer number of patients that undergo radiation as a part of their therapy regimen is only increasing. As this number increases, so does the incidence of secondary, radiation-induced neoplasias, creating a need for therapeutic agents targeted specifically towards reduction in the incidence of and treatment of these cancers. Development and efficacy testing of these agents requires not only extensive class="apple-converted-space" style="font-size:12px;font-family:Verdana;">? style="font-size:12px;font-family:Verdana;">in vitro class="apple-converted-space" style="font-size:12px;font-family:Verdana;">? style="font-size:12px;font-family:Verdana;">testing, but also a set of reliable animal models to accurately recreate the complex situations of radiation-induced carcinogenesis. The laboratory mouse class="apple-converted-space" style="font-size:12px;font-family:Verdana;">? style="font-size:12px;font-family:Verdana;">Mus musculus class="apple-converted-space" style="font-size:12px;font-family:Verdana;">? style="font-size:12px;font-family:Verdana;">remains the most relevant animal model in cancer research due to the molecular and physiological similarities it shares with man, its small size and high rate of breeding in captivity, and its fully sequenced genome. In this work, we review relevant class="apple-converted-space" style="font-size:12px;font-family:Verdana;">? style="font-size:12px;font-family:Verdana;">M. musculus style="font-size:12px;font-family:Verdana;">inbred and?F style="font-size:12px;font-family:Verdana;">1 class="apple-converted-space" style="font-size:12px;font-family:Verdana;">? style="font-size:12px;font-family:Verdana;">hybrid animal models, as well as methods of induction of radiation-induced lung cancers. Associated molecular pathologies are also included.

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摘要:Purpose: The purpose of this study was to explore the supportive care needs and health-related quality of life (HRQoL) of lung cancer survivors, and to identify the association between patient characteristics, HRQoL and supportive care needs. Method: This was a sub-study of a larger scale survey of cancer survivors' supportive care needs. A total of 48 lung cancer survivors were recruited from a regional teaching hospital, and a three-part structured questionnaire was used to collect 1) socio-demographic and clinical characteristics, 2) supportive care needs and 3) health-related quality of life data. Results: The three most commonly reported unmet needs were all in the health-system information domain: 1) being informed about your results as soon as possible (58%), 2) being informed about cancer which is under control or diminishing (50%), and 3) being informed about things you can do to help yourself get well (46%). The second most common unmet need domain was access to healthcare and ancillary support services. The survivors generally reported satisfactory HRQoL. However, household income and unmet physical and psychological needs were independently associated with HRQoL among these survivors. Conclusion: The high unmet needs in the health-system information area call for a review of the content and amount of information provided to lung cancer survivors. In addition, more attention should be given to lung cancer survivors with low incomes but high physical and psychological unmet needs, who require appropriate follow-up and long-term care of a physical, social and psychological kind....
摘要:

style="font-family:Verdana;font-size:12px;">Aim: The aim of this study was to investigate prognostic factors for survival in patients with advanced NSCLC who receiving second-line chemotherapy. Methods: We retrospectively reviewed data of 116 patients with NSCLC receiving second-line treatments from October 2010 to December 2012 in Clinic for Lung Diseases of Clinical center Nis, Department for Pulmonary Oncology. Thirteen potential prognostic factors were chosen for analysis. Univariate analysis was conducted to identify prognostic factors associated with progression free survival and overall survival. Multivariate analysis included the prognostic significance factors in univariate analysis. Results: The univariate analysis for progression free survival (PFS) and overall survival (OS) was identified to have prognostic significance: style="FONT-FAMILY: ; FONT-SIZE: 10pt" ?=""> style="font-family:Verdana;font-size:12px;">performance style="font-family:Verdana;font-size:12px;">status, style="font-family:Verdana;font-size:12px;">smoking, weight loss, comorbidity, number of meta localization, first-line chemotherapy regimen and response to first-line chemotherapy. Nevertheless, multivariate Cox prortional hazard regression analysis showed that performance status (PFS: p = 0.000, OS: p = 0.000) weight loss 5% (PFS: p = 0.000, OS: p = 0.002), comorbidity (PFS: p = 0.001, OS: p = 0.012) and four places of meta localization (PFS: p = 0.021, OS: p = 0.021) were considered independent prognostic factors for both, progression free survival and overall survival. style="font-family:Verdana;font-size:12px;">Conclusion: style="font-family:Verdana;font-size:12px;">Performance status, weight loss 5%, comorbidity and higher number of meta localization were identified as prognostic factors for survival in advanced NSCLC patients receiving second-line chemotherapy treatment. These findings may help pretreatment prediction of survival and may facilitate in the future integration new agents into second-line treatment.

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摘要:Cancer is one of the leading causes of death in America, and there is an urgent need for new therapeutic approaches. The progesterone receptor membrane component 1 (PGRMC1) is a cytochrome style="font-size:12px;font-family:Verdana;">b style="font-size:12px;font-family:Verdana;">5 style="font-size:12px;font-family:Verdana;"> related protein that binds heme and is associated with signaling, apoptotic suppression and autophagy. PGRMC1 is essential for tumor formation, invasion and metastasis, and is name="OLE_LINK5"> name="OLE_LINK3"> style="font-size:12px;font-family:Verdana;">upregulated in breast, colon, lung and thyroid tumors. In the present study, we have analyzed PGRMC1 levels in over 600 tumor sections, including a larger cohort of lung tumors than in previous studies, and report the first clinical analysis of PGRMC1 levels in human oral cavity and ovarian tumors compared to corresponding nonmalignant tissues. PGRMC1 was highly expressed in lung and ovarian cancers and correlated with patient survival. PGRMC1 has been previously associated with drug resistance, a characteristic of cancer stem cells. The stem cell theory proposes that a subset of cancerous stem cells contribute to drug resistance and tumor maintenance, and PGRMC1 was detected in lung-tumor derived stem cells. Drug treatment with a PGRMC1 inhibitor, AG-205, triggered stem cell death whereas treatment with erlotinib and the ERK inhibitor, PD98059, did not, suggesting a specific role for PGRMC1 in cancer stem cell viability. Together, our data demonstrate PGRMC1 as a potential tumor biomarker across a variety of tumors, as well as a therapeutic target for cancer stem cells....
摘要:Non-small cell lung cancer (NSCLC) is the primary cause of cancer related death worldwide. After resection of early stage NSCLC style="font-family:Verdana;">, style="font-family:Verdana;"> the benefit of adjuvant chemotherapy for patient survival still remains unclear and investigations for further risk stratification are needed for an improved treatment decision. Microvessel density (MVD) influences both the nutrition of the cancer and the access to the bloodstream for the development of distant metastasis. The aim of this study was to examine the prognostic significance of microvessel density by CD31 staining in patients with resected stage IA-IIIB NSCLC. We used immunohistochemistry (IHC) of CD31 to examine the microvessel density in a cohort of 69 patients who had undergone radical resection for NSCLC. Correlation of IHC values and standard clinicopathologic parameters was analyzed as well as influence on long term survival. style="font-family:""> style="font-family:Verdana;">Survival analysis revealed a significant better overall survival for patients with higher median microvessel density (log rank p style="font-family:""> style="font-family:Verdana;">= style="font-family:""> style="font-family:Verdana;">0.031) independent of clinicopathologic parameters. Regarding primary cancer related death, the survival was again significantly longer in patients with high CD31 count (log rank p style="font-family:""> style="font-family:Verdana;">= style="font-family:""> style="font-family:Verdana;">0.036). A higher microvessel density was a strong predictor for a longer tumor related survival and could be used for therapeutic decisions of adjuvant chemotherapy after resection of early stage NSCLC....
摘要: style="text-align:justify;"> In the past decades a lot of investigations were focused on searching for more accurate markers of lung cancer progression. Researchers indicate that molecular markers may be useful in forecasting of treatment outcome and overall survival rate in patients with non-small cell lung cancer. The aim of our research was to create a forecasting model in order to identify patients with stage I-II of non-small cell lung cancer and dismal prognosis. Our research covered 254 patients with the early stage of non-small cell lung cancer who underwent a cure from June 2008 till December2012 inthe Department of Thoracic Surgery of Zaporizhzhia Regional Clinical Oncologic Dispensary. Surgery was performed for all patients. Adjuvant chemotherapy was performed for 101 patients. In order to carry out multivariate Cox-regression analysis, STATISTICA 6.0 (StatSoft Inc.) program was used. The most significant from 39 variables were selected (tumor size, histological form of tumor, volume of surgical intervention, volume of conducted lymph node dissection, Ki-67 expression, EGFR expression, E-cadherin expression). We propose the computer system which can forecast survival rate in patients with the early stage of non-small cell lung cancer.

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摘要:

style="font-family:Verdana;line-height:2;font-size:12px;">Small cell lung cancer [SCLC] is a devastating form of cancer, with most patients harbouring extensive disease at diagnosis and survival of less than 5% at five years. Progress in novel therapies has been limited. This specialist review explores current targeted therapy options and potential areas of development.

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摘要:Metastases are synonymous of malignant neoplasm in advanced stage and so associated with a poor prognosis. As the first manifestation of cancer disease, the muscle metastasis is very rare. The definitive diagnosis of its presence is made based on histology. The authors presented the case of a patient with a lung adenocarcinoma, being with first manifestation of it, a muscle metastasis only about a month later there were clinical manifestations with imaging appearance that led to the diagnosis of a primary neoplasm. The rare manifestation of the disease motivated the study and surveillance of the patient and lead to the diagnosis....
摘要:Introduction: Satraplatin has been given in combination therapy for lung cancer to utilize its radio-sensitizing properties. The optimal dose of satra-platin given concurrently with radiation therapy for locally advanced non-small cell lung cancer (NSC-LC) has not been defined. This phase I trial attempts to identify a maximally tolerated dose (MTD) and dose limiting toxicity (DLT) for Satraplatin given con-currently with radiation for locally advanced N-SCLC. Patients and Methods: 15 patients with histologically confirmed Stage IIIA/B NSCLC entered onto this study with four dose escalations (10 to 40 mg daily) of Satraplatin. Eligibility included patients with NSCLC and one of the following criteria: 1) previously untreated, inoperable disease and planned to receive radiation therapy to primary disease site; 2) previously resected disease with mediastinal relapse; or 3) metastatic disease in no more than one distant site. Results: The most common toxicities reported were all grades of fatigue (n = 9), nausea (n = 9), constipation (n = 7), fever (n = 7), and vomiting (n = 6). No DLT at the 1st, 2nd, and 3rd dose levels was identified. At the 4th dose level, one patient developed grade III elevation of liver function tests (LFTs) and a second patient developed grade III diarrhea with fever requiring hospitalization. There were 8 partial responses out of 11 evaluable patients for response (RR 67%). Conclusion: Elevated LFTs and diarrhea appear to be the principal DLTs of concurrent daily oral Satraplatin and thoracic radiation in the outpatient setting. The MTD of concurrent Satraplatin with thoracic radiation therapy appears to be 40 mg daily....
摘要: align="justify"> style="font-family:Verdana;">Background: Percutaneous ablation therapy as a treatment for non-small cell lung cancer (NSCLC) has been increasingly utilized. There is little data on long term efficacy. Because of this we reviewed the rate of recurrence of all ablation procedures done at our institution for the last 6 years. Methods: A total of 36 patients underwent 43 percutaneous procedures from July 2008 until January 2014 at our institution. There were 9 patients treated with radiofrequency ablation (RFA) and 27 treated withmicrowave ablation (MWA) for Stage I NSCLC. Each patient was reviewed to determine if there was a recurrence, the time to recurrence and the characteristics of the original cancer possibly predisposing the procedure to failure. Results: There were 8 recurrences in 9 patients undergoing RFA occurring at a median time of 842 days (range 425 - 1568) after their procedure. MWA was utilized in 27 patients for 34 procedures with 11 patients experiencing recurrences at a median time of 487 days (range 168 - 845). The median follow up time for the RFA patients was 1631 days (4.46 years) and for the MWA patients 751 days (2.06 years). Of the RFA recurrences, 5 involved systemic spread of their cancer and 3 were limited to site recurrences only. Of the MWA recurrences, 5 involved systemic spread of their cancer, 2 had chest wall recurrences and 4 were limited to site recurrences only.

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