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[期刊论文] Guo-Wei ZHOU Hui HUANG
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CSTPCD 北大核心 SCI
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摘要:Endosymbiotic dinoflagellates in the genus Symbiodinium are among the most abundant and important group of photosynthetic protists found in coral reef ecosystems.In order to further characterize this diversity and compare with other regions of the Pacific,samples from 44 species of scleractinian corals representing 20 genera and 9 families,were collected from tropical reefs in southern Hainan Island,China.Denaturing gradient gel electrophoresis fingerprinting of the ribosomal internal transcribed spacer 2 identified 11 genetically distinct Symbiodinium types that have been reported previously.The majority of reef-building coral species (88.6%) harbored only one subcladal type of symbiont,dominated by host-generalist C1 and C3,and was influenced little by the host’s apparent mode of symbiont acquisition.Some species harbored more than one clade of Symbiodinium (clades C,D) concurrently.Although geographically isolated from the rest of the Pacific,the symbiont diversity in southern Hainan Island was relatively low and similar to both the Great Barrier Reef and Hawaii symbiont assemblages (dominated by clade C Symbiodinium).These results indicate that a specialist symbiont is not a prerequisite for existence in remote and isolated areas,but additional work in other geographic regions is necessary to test this idea....
摘要:目的:评估CT平扫对肾结石化学成分的预测价值.方法:收集自2009年7月~2011年1月在我科获取的160例肾结石标本.患者在治疗前均采用GE Highspeed/i螺旋CT泌尿系平扫测量肾结石的最大横径及结石的平均CT值,并将获取的肾结石标本采用红外线光谱自动分析系统进行化学成分定性分析,经统计学处理找出各种纯结石的相应的CT值范围.结果:纯尿酸结石(498.7 ±51 HU)与其他成分的结石( 879.5±198.6 HU) CT值之间的差异有统计学意义(P<0.05).结论:CT值<550HU的结石多为尿酸结石...
[期刊论文] 朱顺兰 黄蕙 张四平
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北大核心 CSTPCD
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摘要:为了克服控制算法因鲁棒性差难以实现对不确定性复杂关联系统控制的缺陷,探讨了仿人智能融合控制算法的鲁棒性。讨论了传统控制面临的挑战,粗略地分析了不确定性复杂关联系统的控制论特性,研究了系统的仿人智能融合控制策略,针对具体对象构造了相应的控制算法。以二阶时滞对象控制为例,分别采用PID与仿人智能融合控制算法进行了仿真对比研究,实验的系统响应曲线验证了该算法具有良好动静态控制品质与鲁棒性能。研究结果表明:提出的融合控制算法是可行与合理的,具有很强的鲁棒性。...
摘要:Symbiotic algae (Symbiodinium sp.) in scleractinian corals are important in understanding how coral reefs will respond to global climate change. The present paper reports on the diversity of Symbiodinium sp. in 48 scleractinian coral species from 25 genera and 10 families sampled from the Xisha Islands in the South China Sea, which were identified with the use of restriction fragment length polymorphism (RFLP) of the nuclear ribosomal DNA large subunit gene (rDNA). The results showed that: (i) Symbiodinium Clade C was the dominant zooxanthellae in scleractinian corals in the Xisha Islands; (ii) Symbiodinium Clade D was found in the corals Montipora aequituberculata, Galaxea fascicularis, and Plerogyra sinuosa; and (iii) both Symbiodinium Clades C and D were found simultaneously in Montipora digitata, Psammocora contigua, and Galaxeafascicularis. A poor capacity for symbiosis polymorphism, as uncovered by RFLP, in the Xisha Islands indicates that the scleractinian corals have low adaptability to environmental changes. Further studies are needed to investigate zooxanthellae diversity using other molecular markers....
摘要:Objective: To investigate whether there is a correlation between nonalcoholic faty liver disease (NAFLD) and arrhythmia on electrocardiogram. Methods: A retrospective controlled study was performed on the electrocardiogram of 200 patients admited to our department of cardiology. The study excluded patients with smoking history, drinking history, congenital heart disease, and malignant tumors. According to the ultrasound examination criteria, NAFLD was diagnosed by abdominal ultrasound examination and electrocardiogram (ECG) examination, which was analyzed by cardiovascular experts to assess NAFLD and baseline characteristics, clinical features, drug use, and arrhythmia ECG changes by univariate logistic regression analysis. Multivariate logistic regression was used to determine whether NAFLD is one of the most important factors affecting arrhythmia. Results: Of the 200 patients, 116 were found to have NAFLD and 84 were without NAFLD. Among them, a total of 91 arrhythmias occurred in 76 patients, as follows: 30.2% (23 cases) sporadic atrial premature beats, 51.3% (39 cases) occasional ventricular premature beats, 19.7% (15 cases) frequent ventricular premature beats, 10.5% (8 cases) multi-source atrial premature beats complicated with short-term atrial tachycardia, 3.9% (3 cases) atrial fibrillation and 3.9% (3 cases) short-term ventricular tachycardia. Univariate logistic regression analysis found that including gender (male), coronary artery disease, hypertension, diabetes, arrhythmia ECG changes (occasion of premature atrial premature beats, occasional premature ventricular contractions, frequent ventricular premature beats, multi-source atrial premature beats Short-term atrial tachycardia, atrial fibrillation, and short-term ventricular tachycardia were positively correlated with NAFLD. Five risk factors for the following arrhythmias were identified using multivariate regression model analysis: NAFLD (OR = 2.35; 95%CI: 1.46-3.83, P < 0.001), coronary artery disease (OR = 2.56; 95%CI: 1.58-4.11, P < 0.001), hypertension (OR = 2.98; 95%CI: 1.52-6.31, P < 0.001), male (OR = 1.78;95%CI: 1.18-2.70, P < 0.001) and age (OR = 1.04; 95%CI: 1.02-1.06, P < 0.001). Conclusion: NAFLD is associated with arrhythmia ECG changes....
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CSTPCD CSCD CA CBST
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摘要:目的:比较卵母细胞体外成熟培养液中添加不同促性腺激素对未成熟卵母细胞体外成熟结局的影响.方法:将行卵母细胞体外成熟(IVM)的35例患者共42个新鲜取卵周期,随机分成A组:22个取卵周期将重组人促卵泡激素(果纳芬,rFSH)和重组人绒毛膜促性腺激素(艾泽,hCG)按1∶1的比例混合添加,终浓度为75 mlU/ml;B组:20个取卵周期添加终浓度为75 mlU/ml的尿源性促性腺激素(hMG),进行未成熟卵母细胞体外成熟培养.35例患者中新鲜取卵周期未移植或移植后未孕者行解冻胚胎移植.比较组间患者的卵母细胞成熟率、受精率、卵裂率、优质胚胎率、累计临床妊娠率及胚胎着床率.结果:取卵均于月经周期第12日或最大卵泡发育至10~12 mm时进行,故所获卵均为未成熟卵.A组获卵181枚,经培养后成熟84枚,行卵胞浆内单精子注射(ICSI)84枚,受精60枚,卵裂55枚,优质胚胎20枚;新鲜胚胎移植9例,获1例临床妊娠,解冻胚胎移植5例,获1例临床妊娠,累计临床妊娠率为14.29%,胚胎着床率为7.14%.B组获卵176枚,经培养后成熟120枚,行ICSI 120枚,受精97枚,卵裂90枚,优质胚胎41枚,新鲜胚胎移植6例,获4例临床妊娠,解冻胚胎移植9例,获3例临床妊娠,累计临床妊娠率为46.67%,胚胎着床率为33.33%.结论:卵母细胞体外成熟培养液中添加尿源性促性腺激素可获得较添加重组人促卵泡激素和重组人绒毛膜促性腺激素高的卵母细胞成熟率、临床妊娠率及胚胎着床率....
摘要:Well-defined spinel LiMn2O4 powders were synthesized via sintering a precursor, which was prepared by spray-drying method. The effects of sintering process on the structure and electrochemical properties of LiMn2O4 were discussed. It was found that a single sintering could not synthesize a pure LiMn2O4 compound, while two-step sintering procedure consisting of decomposing sprayed precursors at 350℃ and further sintering at an elevated temperature leads to the formation of a single-phased LiMn2O4 with homogeneous particle size distribution. As compared to that sintered in air, the two-step sintered LiMn2O4 in oxygen shows tighter structure and more uniform particle size, as well as better electrochemical properties. It delivers an initial discharge capacity of 131 mAh·g-1 (1/10C), and still has excellent cycling stability at higher rate (1/5C)....
摘要:The α-PbO_2 electrodes are prepared by anodic electrodeposition on Al/conductive coating electrode from alkaline plumbite solutions in order to investigate the effect of the different current densities on the properties of α-PbO_2 electrodes. The physic-ochemical properties of the α-PbO_2 electrodes are analyzed by using SEM, EDS, XRD, Tafel plot, linear sweep voltammetry (LSV) and A.C. Impedance. A compact and uniform layer of lead dioxide was obtained at the current density of 3 mA-cm~(-2) . A further increase in current density results in smaller particles with high porosity. EDS and XRD analyses have shown that the PbO_2 deposited in alkaline conditions is highly non stoichiometric, and the PbO impurities are formed on the surface layer besides the α-PbO_2. The corrosion resistance of α-PbO_2 at the low current density is superior to that of the high current density. It can be attributed to a porous layer of deposited films at high current densities. When used as anodes for oxygen evolution in aqueous Zn~(2+) 50 g·L~(-1), H_2SO_4 150 g·L~(-1), the Al/conductive coating/α-PbO_2 exhibits lower potential compared to Pb electrode. Al/conductive coating/α-PbO_2 electrode with the best electrocatalytic activity was obtained at current density of 1 mA·cm~(-2). The lowest roughness factor was obtained at 1 mA·cm~(-2)....
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北大核心 CSTPCD AJ
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摘要:目的 探讨在膝关节关节镜手术中局部麻醉的可行性和优越性.方法 用2%利多卡因20.0 m1+1%盐酸肾上腺素0.5 ml+生理盐水30.0 ml做穿刺点局部浸润麻醉及关节腔内表面麻醉,观察186例局麻下行膝关节关节镜手术患者的麻醉满意度及手术效果.结果 所有患者均按计划完成膝关节关节镜下手术,术后无麻醉并发症发生,患者术中麻醉满意度达94.62%.根据日本骨科协会评估治疗分数(JOA)膝骨性关节炎治疗效果判定标准,术后半年平均得分92.5分.术后半年按患者的主观评定分级,优良率达91.94%.结论 局部麻醉可满足部分膝关节疾病关节镜手术的需要,局麻下行膝关节关节镜手术完全可行,有安全、简便、对全身状况影响小、麻醉并发症少和费用少等优点....
摘要:采用密度泛函理论DFT/B3LYP/6-31G+(d, p)方法计算不同配位形态的铜、镍萃合物的结合能、全局活性指数、局部活性指数和红外光谱,探讨了1-苯基-1,3癸二酮(Mextral54-100)萃取Cu(II), Ni(II)的行为及机理.结果表明,Mextral54-100对Cu(II)的萃取能力大于Ni(II).在反萃过程中,铜的萃合物更易被反萃.萃合物羰基表现出最高的反应活性,为活性中心.萃合物中氨分子的取代数越多,萃合物构型近似于稳定的八面体结构.配体氨逐一被萃取剂的羰基取代,有效避免共萃氨.Mextral54-100从铜、镍氨混合溶液中萃取–反萃Cu(II)和Ni(II)的实验结果与理论预测结果吻合,进一步通过FT-IR证实了理论计算结果的准确性,密度泛函理论有望成为一种研究萃取分离性能的新方法....
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北大核心 CSTPCD CSCD CA CBST
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摘要:目的:利用系统生物学技术分析中药复方金龙胶囊抗脑肿瘤的分子机制。方法:取金龙胶囊组及空白对照组小鼠的原位脑肿瘤组织样本进行基因芯片检测,通过比对获取差异基因;使用一步过连通测算和多步骤隐藏节点测算获得拓扑基因;采用富集分析法分析其生物功能;借助MetaCore平台构建分子机制网络图。结果:与对照组相比,金龙胶囊组共有37个差异基因(倍数>2),106个拓扑基因。金龙胶囊的靶点主要集中在细胞粘附和凋亡、免疫应答、神经组织发育等。结论:金龙胶囊通过诱导神经细胞特有基因表达和抑制干扰素信号转导发挥抗脑肿瘤作用。...
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北大核心 CSTPCD CSCD CA CBST
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摘要:目的:肺部是分化型甲状腺癌(differentiated thyroid carcinoma,DTC)的常见转移部位,131I治疗是DTC术后患者肺转移的主要治疗方法,其治疗后常规行131I-全身扫描(whole body scan,WBS),本文主要研究DTC肺转移患者WBS显像中肺部病灶显像的影响因素。方法:回顾性分析在天津医科大学肿瘤医院分子影像与核素诊疗科行131I治疗的DTC肺转移患者60例,治疗前均行甲状腺功能检测、颈胸部CT检查,治疗后行WBS显像。根据WBS肺部转移灶显像情况将患者分为显像阳性组和显像阴性组,分析相关影响因素。结果:单因素分析提示,患者的年龄、肺部纤维条索影、钙化影、斑片影等与WBS肺部显像情况相关。双变量Logistic回归分析提示肺部纤维条索影(OR=0.175,P<0.001)及钙化影(OR=0.088,P<0.05)不利于WBS肺部转移灶的显像。结论:年龄较大患者的WBS肺部病灶显像效果不佳,肺部存在条索影、钙化影、斑片影等不利于WBS肺部转移灶的显像,肺部条索及钙化是影响WBS肺转移灶显像的主要因素。...
摘要:通过使用光学显微镜、扫描电镜、透射电镜及X射线衍射等手段研究一种新型Er、Zr微合金化Al-Zn-Mg-Cu合金在均匀化过程中的显微组织演变.结果表明:铸态合金组织存在严重的偏析,此时合金中含有大量的T(AlZnMgCu)、S(Al2CuMg)和Al8Cu4Er相,这些初生相大量偏聚于晶界.随着在465℃单级均匀化处理的进行,第二相含量大幅度降低,可熔的T相和S相会逐步地熔入基体,但Al8Cu4Er相不能完全消除,仍有少量残留.相对于单级均匀化工艺,合金在双级均匀化处理时不仅能够消除铸态合金偏析组织,而且能够析出大量细小弥散分布的L12结构的Al3(Er,Zr)相.结合均匀化动力学分析,可以得出合金合理的均匀化热处理制度为(400℃,10 h)+(465℃,24 h)....
摘要:以M5640为萃取剂,在CO2协同作用下,从氨-硫酸铵溶液中萃取锌,考察了萃取剂浓度、总氨浓度、相比、温度、加入CO2等因素对锌萃取率的影响.结果表明,M5640在氨性溶液中对锌有一定的萃取能力,溶液pH值和总氨浓度对锌的萃取率影响较大,向溶液中加入CO2可明显提高M5640对锌离子的萃取能力.在温度25℃及M5640加入量35v01%、相比O/A=2、锌离子浓度18.02g/L、总氨浓度3 mol/L的条件下,加入CO2锌的单级萃取率由不加CO2时的65.1%提升至97%以上,两级错流萃取锌萃取率达99.9%.萃取得到的有机相不含氨,表明加入CO2可避免氨的共萃....
摘要:背景与目的肺癌居于全球男性及女性癌症相关死亡原因的首位,大多数患者在确诊时已属晚期,5年生存率仅为18%。肺癌可分为非小细胞肺癌(non-small cell lung carcinoma, NSCLC)和小细胞癌(small cell lung carcinoma, SCLC),其中NSCLC占肺癌的80%-85%,NSCLC根据组织学可主要分为腺癌(约占40%),鳞状细胞癌(20%-30%)和大细胞癌(10%),针对驱动基因的靶向治疗在肺腺癌中取得一定成绩,但在肺鳞癌的治疗中收效甚微,肺鳞癌的诊治更需得到关注,18F-脱氧葡萄糖(lfuorodeoxyglucose, FDG)正电子发射断层扫描/计算机体层摄影(positron emission tomography/computed tomography, PET/CT)越来越多地应用于肺癌的诊断与分期中,本研究旨在探讨18F-FDG PET/CT原发灶最大标准摄取值(maximum standardized uptake value, SUVmax)在肺鳞癌患者术后预后中的意义及与临床病理特征的关系。方法回顾分析2005年5月-2014年10月收治的182例初治、接受PET/CT检查、行根治术的原发肺鳞癌患者的临床影像病理及随访资料。采用Kaplan-Meier法及Cox模型分析患者生存情况,并分析原发灶SUVmax与各临床病理因素的关系。结果182例肺鳞癌患者原发灶SUVmax以13.0为界分为两组,SUVmax>13.0组与≤13.0组患者的中位总生存期分别为56个月和87个月,差异具有统计学意义(P=0.022)。原发灶SUVmax与性别、肿瘤最大径、肿瘤-淋巴结-转移(tumor-node-metastasis, TNM)分期、中性粒细胞、中性粒细胞/淋巴细胞比例(neutrophil-lymphocyte ratio, NLR)存在正相关性,与血红蛋白呈负相关(P<0.05)。Cox多因素分析显示SUVmax (HR=1.714,95%CI:1.021-2.876, P=0.042)、TNM分期(HR=1.677,95%CI:1.231-2.284, P=0.001)均为患者生存的独立预后影响因子,提示SUVmax有独立于病理TNM分期之外的预后价值。而且,SUVmax在I期肺鳞癌患者的预后中有意义(P=0.045)。结论 PET/CT SUVmax对肺鳞癌患者术后生存的预测有重要的价值,是独立于TNM分期之外的一个重要预后因素,并且原发灶SUVmax与多个临床病理因素间存在相关性。...
摘要:通过电化学氧化共沉积技术在A1/导电涂层/α-PbO2-CeO2-TiO2基体上,制备了A1/导电涂层/α-PbO2- CeO2-TiO2/β-PbO2-MnO2-WC-ZrO2复合阳极材料。通过能量色散X射线光谱(EDXS)、阳极极化曲线、暂稳态极化曲线(Tafel)、交流阻抗谱(EIS)、扫描电子显微镜(SEM)以及 X 射线衍射(XRD)等方法研究电流密度对复合阳极材料的化学组分、电化学活性和稳定性的影响。研究结果表明:在电流密度为1 A/dm2条件下制备的A1/导电涂层/α-PbO2-CeO2-TiO2/β-PbO2-MnO2-WC-ZrO2复合材料具有最低的析氧过电位(0.610 V,条件:500 A/m2),最好的电化学活性,最长的使用寿命(360 h,条件:150 g/L H2SO4,2 A/cm2,40°C)以及最低的槽电压(2.75 V,条件:500 A/m2)。而且,随着电流密度的增加,涂层晶粒逐渐增大,MnO2含量也逐渐降低,晶体结构几乎没有变化。...
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