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中国中西医结合杂志
CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
2005 Vol.25 No.6 P.549-551

数字化期刊

从分子水平研究补肾法对性早熟与衰老的调控规律

沈自尹  蔡德培 

摘 要:肾阴肾阳失衡是性早熟和衰老的病理基础,衰老是"生理性肾虚",其阴阳失衡是以肾阳虚为主;性早熟的本质是阴虚火旺,其阴阳失调是以肾阴虚为主.由肾气盛衰主导的生长、发育、衰老过程中,主要涉及生长激素轴和性腺轴,性早熟患儿可见这两轴的提前启动,表现为阴虚火旺;而衰老时是这两轴的率先衰退,表现为阳气虚损.分别采用温补肾阳方药以延缓衰老与滋阴泻火方药以抑制性早熟取得临床与实验的显著效果,通过以药测证,推测发病部位,证明性早熟或衰老,其病理损害是在下丘脑或更高中枢.
关键词:衰老;性早熟;肾阴;肾阳;下丘脑

Study on the Regulative Rule of Reinforcing Shen Principle on Sexual Precocity and Senescence at the Molecular Level

SHEN Zi-yin  CAI De-pei 

基金项目:国家自然基金资助项目(No.30271666);卫生部科研基金项目(No.98-1-172)
作者简介:沈自尹,Tel:021-62489999转6311,Fax:02162490934, E-mail: ziyinshen@21cn. Com; 通讯作者
作者单位:沈自尹(复旦大学附属华山医院中西医结合研究所,上海,200040) 
     蔡德培(复旦大学附属儿科医院中西医结合研究室) 

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收稿日期:2004年5月29日

修稿日期:2005年3月21日

出版日期:2005年6月20日

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