Objective To evaluate the efficacy and safety of argon plasma coagulation (APC) for gastric low-grade intraepithelial neoplasia (LGIN). Methods We selected prospectively patients with gastric low-grade intraepithelial neoplasia in our hospital and performed APC under endoscopic. Pain score were recorded by using Wang-Baker facial pain scale. A month later, patients underwent regular endoscopy follow-ups. Results A total of 50 patients were included in the study from October 2013 through June 2014. 44 patients underwent endoscopy follow-ups after one month and the effective ratio of the treatment was 81.8%, There were 3 cases (9.4%) with ulcer, the rest of the performance for different degree of scarring. There were no treatment-related complications, such as bleeding or perforation. Postoperative pain score mostly distributed in 2 to 6 points. Conclusion APC is considered to be safe and effective, less painful and can be performed in the outpatient service.