Objective To determine whether skin friction coefficient (SFC) is associated with gender and age in a normal Chinese Han population. Methods A total of 414 Chinese Han subjects including 187males and 227 females, who were aged from 0.15 to 79 years (mean age: 35.80 ± 1.33 years), were enrolled in this study. According to human development stages, subjects were divided into pre-puberty group (aged 0 - 12years), young group (aged 20 - 40 years) and old group (aged 60 - 80 years). SFC and stratum corneum capacitance were measured with A Frictiometer(R) FR 770 and Corneometer(R) CM 825 (C&K MPA 5), respectively,on the dorsal hand, forehead, as well as canthus. Results SFC was higher on the dorsal hand than on the forehead in old males (P ＜ 0.05 ), and higher on the dorsal hand and canthus than on the forehead in young females (both P ＜ 0.001 ), while no significant difference was observed between the three measured sites in other groups of females or males (all P ＞ 0.05 ). In males, SFC on each measured site was similar among the three groups. In contrast, SFC was significantly higher on the forehead of females in aged than in young and pre-puberty groups (both P ＜ 0.01 ), and on the canthus and dorsal hand of females in young than in pre-puberty and aged groups (all P ＜ 0.01 ). The SFC on the canthus and dorsal hands of young females was higher than that of age-matched males (P ＜ 0.0001 and 0.05, respectively). A positive correlation was found between SFC and stratum corneum hydration in young males (foreahead: r = 0.6342, P ＜ 0.0001; canthus: r = 0.4501, P ＜0.001; dorsal hands: r = 0.3627, P ＜ 0.01 ). Moreover, SFC on the forehead (r = 0.2797, P ＜ 0.05) and canthus (r = 0.486, P ＜ 0.001 ) was also positively correlated with stratum corneum hydration in old females.Conclusion Skin friction coefficient varies with age, gender, body sites and stratum comeum hydration in normal Han populations.