[ABSTRACT]Objective: To investigate the perioperative cataract patients to prevent infection on the occurrence of postoperative intraocular infection control effect. Methods:186 cases of cataract patients according to the disinfection methods were randomly divided into A, B, C three groups, 62 cases in each. Group A: using saline irrigation of conjunctival sac disinfection method. Group B: group A based on the preoperative again povidone iodine disinfection after surgery. Group C: group B based on the postoperative of povidone iodine directly after wound dressing.Results:The positive rate of pathogenic bacteria: before disinfection, group A was 53.2%, group B was 58.06%, group C was 56.45%; after disinfection, group A was 11.29%, group B was 12.90%, group C is 9.68%, three groups after disinfection were than before disinfection decreased significantly(P<0.05), but between the three groups of patients with no significant difference(P>0.05). After disinfection, there was no significant difference in the incidence of adverse reactions between the three groups(P>0.05). After disinfection, the incidence of ocular discomfort in group A was significantly lower than that in group B and group C(P<0.05).Conclusion:Perioperative infection prevention in patients with cataract can effectively control the growth of ocular pathogens and reduce the incidence of postoperative intraocular infection.