Objective: To investigate the possibility and safety of misoprostol to end gestation for pre-eclampsia and to observe the effect of magnesium sulphate (MgSO4) on the bleeding in and after dilivery. Methods: 62 primiparas with pre-eclampsia, singal pregnant, vertex present were selected. All cases had indications for labor induction. The 62 women were randomly divided into two groups.32 cases used misoprostol for induction was the study group. 30 cases used oxytocin served as the control group. The use of magnesium sulphate during birth timewas no difference between the two groups. Results: The total effectual rate of induced labor was 96.9% in study group, and
73.3% in control group,there was significant difference between them(P＜0.01).The rate of cesarean section of the study group (18.8%) was significantly higher than that of the control group (46.7%) (P＜0.01). Theincubation period of puerpera used magnesium sulphate was obviously longer thanthat of those who didn't take magnesium sulphate(P＜0.05). But the total dilivery time didn't prolong (P＞0.05). There was no difference in the volume of postpartum bleeding between two groups (P＞0.05). Conclusions: The misoprostol used in pre-eclampsia vaginally for induced labor is effective, safe, convenient and worth extending.