Objective To acquire the effect of gallium salt on preventing and treating osteoporo sis. Methods The experiment was composed of two steps:①Duplicating an animal model of osteo porosis; ②Treating the rats with gallium salt. Results ①All the experimental parameters of osteo porosis decreased and had significant difference compared to those of the controls;②The pathologic bone resorption changes in therapeutic group are alleviated and have significant difference in compar ison to control group. The bone intensity also appeared an improving trend. Conclusion Gallium salt has therapeutic effect on osteoporosis or is able to retard the progress of this disease.