ABSTRACT:This article reviewed the kinds and damage of common pesticides, latest detection technique and pretreatment methods about pesticide residues in complex food matrix. Solid phase extraction, gel permeation chromatography, microwave assisted extraction and dispersive solid phase extraction technologies were mainly summarized. The detection technology of pesticide residues mainly used chromatography methods. This paper focused on the gas chromatography, liquid chromatography methods and the corresponding mass spectrometry method. The development of high resolution mass spectrometry technology can provide strong support for the establishment of pesticide residue detection and monitoring system. The pesticide residues monitoring system, software system and database based on the main pesticide residues concerned in grain and oil food were proposed, which can be used in the pesticide residues risk screening system. This pesticide residues screening system can be used for government and industry to master the pollution situation of pesticide residues in agricultural products and to propose the practical solution.