For ensuring safe reuse of reclaimed water irrigation (RWI), the effect of irrigation with reclaimed water on quality and yield of winter wheat and summer corn was researched. The experimental results showed that the yields of winter wheat and summer corn which irrigated with reclaimed water increased by 6.49% and 5.42%, respectively, compared with those of freshwater irrigation treatment. There was no significant difference between reclaimed water irrigation treatment and freshwater irrigation treatment (α=0.05). The crude protein content, soluble sugar content, crude ash, crude starch and reduced vitamin C content had little varied, but showed no consistent trend for reclaimed water irrigation. The main quality indexes of winter wheat and summer corn with reclaimed water irrigation had not been significantly influenced (α=0.05). The total nitrogen content in grains of winter wheat, total nitrogen and total phosphorus contents in grains of summer corn were increased slightly, but the total phosphorus and total potassium contents in grains of winter wheat, total potassium content in grains of summer corn had no significant variation with reclaimed water irrigation.