To establish a rapid detection method for the determination of dichlorvos,methamidophos and other organophosphorus pesticide residues in vegetables and grains by gas chromatography?mass spectrometry ( GC?MS ) , samples were first extracted with acetonitrile and pretreated by QuEChERS method,then detected by gas chromatography?mass spectrometry under multiple reaction monitoring. 16 kinds of organophosphorus pesticides could be detected within 15 min with a good separating degree and good linearity. The correlation coefficient range was 0?025?0?4 mg/kg, and the correlation coefficient (R2) were more than 0?94.The standard addition recovery rates of different substrates such as rice,flour, and vegetable were in the ranges of 75?9%?112?2%, 77?3%?126?9%, and 76?2%?125?3% with relative standard deviation ( RSD )<8?5%. The uncertainty of the repeated experiments met the national standards. The method was simple, rapid, high sensitivity, good selectivity, and was suitable for determination of organophosphorus pesticides residues in food.