The kinetics of in situ intestinal absorption of ziprasidone in SD rats was studied from analysis the content of ziprasidone in recirculation fluid with a high performance liquid chromatography ( HPLC) . The in situ single?way perfusion rat model was used for the absorption behaviors of ziprasidone in each intestinal segment of rats. The effect of drug concentration and the bile salt on the intestinal absorption were also investigated. Results showed that ziprasidone was absorbed in the total intestinal with the absorption rate constant ( K ) of duodenum of ( 4?69 ± 0?33 ) and ( 2?61 ± 0?37 ) h-1 in colon. The absorption rate constant in duodenum was higher with free access to bile salt compared with the bile duct ligation.With the increase of the concentration of ziprasidone,the absorption rate constant was increased. The absorption of ziprasidone occurred via the simple diffusion.