Objective To test the reliability and validity of Chinese version of the Brief Illness Perception Questionnaire in patients with breast cancer. Methods Three hundred patients with breast cancer were investigated with the Chinese version of the BIPQ (The Brief Illness Perception Questionnaire) and Sense of Coherence-13. The reliability and validity of the Chinese version of the BIPQ were tested. Results The Cronbach’s α and split-half reliability of BIPQ was 0.77 and 0.81 respectively. The scores of items were significantly correlated with the total score (P<0.01). The correlation coefficient between BIPQ and SOC-13 was -0.671 (P<0.01). Factor analysis supported the three-factor structure of the original scale, which could explain 74.391% of the total variance. Conclusion The Chinese version of BIPQ has good reliability and validity ,which can be used as a valid tool for the measurement of illness perception in patients with breast cancer in China.