~(18)F and ~(11)C marked tropane derivatives is routing used PET tracer. ~(11)C marked ~(11)C-2?carbomethoxy-3?(4-fluorophenyl) tropane (~(11)C-CFT) synthesis method is simple, have high specific activity and low cost, but ~(11)C short half life limited the clinical application of ~(11)C-CFT. ~(18)F-CFT was much accounted of due to long half life and easy-to-access. ~(11)C-CFT and ~(18)F-CFT was both used in Parkinson disease early diagnosis and monitoring of pharmaceutical therapy.