Objective The present study was conducted to gain insight into the epidemic characteristics of hand-foot-mouth disease cluster cases in Beijing, 2010, so as to provide reference data for prevention and control of hand-food-mouth disease. Methods Analysis was made on the data of hand-food-mouth disease cluster cases in Beijing in 2010, and descriptive epidemiology was used to analyze the data. Results A total of 1350 hand-food-mouth disease cluster cases and 81 outbreaks were reported in Beijing in 2010.Both the cluster cases and outbreaks occurred mainly in kindergartens, and 35.86% kindergartens reported cluster cases in 2010. More cluster cases were found near the city center. Cluster cases could be found in all seasons, and lasted shorter with early prevention and control measures. Infected children lived near the city center were younger than other areas. The pathogenic distribution of ordinary cluster cases and the outbreaks was coincident. Conclusion Some comprehensive measures can postpone, decrease, and even stop the spread of hand-food-mouth disease in children Better implementations of routine prevention and control measures should be. Taken to reduce the number of cases and outbreaks.