Negative pressure wave technique is an effective method for pipeline leak detection. In order to obtain more accurate inflection point information of negative pressure wave and improve signal to noise ratio, experiments using 102.8 meters pipeline experimental platform, according to the negative pressure wave signal captured by the sensors, the response time, static stability and anti-electromagnetic interference of the optical fiber sensor and the traditional electronic pressure sensor are analyzed. Experimental results show that from the leakage of negative pressure wave signal acquisition to the pressure signal restore stability, optical fiber sensor takes about 30 ms, which is far better than the electronic sensor 500 ms. In the static stability experiment, the pressure signal output of optical fiber sensor is stable, and the pressure fluctuation range is ± 0.001 MPa, which is far less than the electronic sensor ± 0.006 MPa. Comprehensive evaluation analysis shows that the optical fiber sensor has good stability and anti-electromagnetic interference performance, and has wide application prospect in the fields of pipeline leakage monitoring, energy and chemical industry.