To predict the failure loads of adhesive joints under different stress states over the service temperature range of automobiles, adhesively bonded carbon fiber reinforced plastic ( CFRP)/aluminum alloy joints under shear stress state ( thick-adherend shear joints, TSJ) , normal stress state ( butt joints, BJ) and combined shear and normal stress states ( scarf joints with scarf angle 45°,SJ45°) were manufactured and tested at-40, -20, 0, 20, 40, 60 and 80℃, respectively. The glass transition temperature Tg of the adhesive and CFRP, failure loads and fracture surfaces were used to analyze the failure mechanism of CFRP/aluminum alloy joints at different temperatures. A response surface, describing the variations of quadratic stress criteria with temperature, was established and introduced into the cohesive zone model ( CZM) to carry out a simulation analysis. Results show that the failure of CFRP/aluminum alloy joints was determined collectively by the mechanical performances of adhesive and CFRP. Besides, reducing temperature or increasing the proportion of normal stress of adhesive layer was more likely to cause fibre tear or delamination of CFRP, resulting in a more obvious effect of CFRP. The validity of the prediction method was verified by the test of scarf joints with the scarf angle of 30°(SJ30°) and 60°(SJ60°) at -10 and 50 ℃.